ADMET definition

ADMET means studies that are designed to examine preliminary adsorption, distribution, metabolism, excretion or toxicology profiles of a Compound in vitro and/or in animals, which may or nay not be conducted under GLP conditions.
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Examples of ADMET in a sentence

  • It should be noted that [***] is committed to provide timely access of the collaboration to its ADMET platforms.

  • Assay selection and validation will be performed by taking [***] Exemplar Compounds from each [***] testing them in a battery of tests including the full [***] profiling platform; in parallel, they will be assessed in a panel of tests within [***] (Physical chemistry, ADME/T and cytotoxicity).

  • After each batch of ACADIA Targets is screened, the Research Committee will review the various combinations of Available Active Compounds and ACADIA Targets for which activity was detected and decide which Available Active Compounds and ACADIA Targets from that batch of screening, if any, should progress to further qualification in secondary screens and ADMET assays as described in the Collaboration Plan and Research Plan.

  • Since our 1996 reorganization, we have focused on alleviating the protein purification and ADMET (absorption, distribution, metabolism, elimination and toxicology) screening bottlenecks in drug discovery.

  • Bionovo will provide all available CMC and ADMET data, at that time, at no additional expense to UBC.

  • Under the Exploratory Development Program, the Parties (either jointly or unilaterally) will conduct Non-Clinical Studies (such as in vivo pharmacodynamics studies, pharmacological studies and ADMET studies) to characterize Lead Compounds, to determine whether any such Lead Compounds should be designated as Development Candidates for IND-enabling Non-Clinical Studies and potentially for Clinical Studies.

  • In the event Bionovo did not secure additional funding for the complete required CMC and ADMET, as required by US FDA, UBC will have the option to negotiate with Bionovo the independent completion the above mentioned CMC and ADMET work.

  • Trimeris agrees not to undertake any IND-Enabling Studies with respect to a particular Focused Library Compound, Lead Compound or Compound until such compound has been designated a Development Compound in accordance with this Section 2.4.4(b); provided however, that Trimeris may undertake to perform non-GLP ADMET studies on Compounds in order to determine whether or not it shall designate a Compound as a Development Compound.

  • The Parties will seek to qualify Collaboration Compounds through additional biological assays, including functional assays, in vitro ADMET assays, bacterial inhibition assays, and other assays identified by the Research Committee.

  • We also have an established product base in ADMET screening which includes precision infusion pumps, organ testing systems and ventilators.