Adjuvare definition
Adjuvare is latin and means to help or aid, which is exactly the purpose of adjuvants. And adjuvant is simply defined as a compound with the ability to increase and/or modulate the immunogenicity of an antigen107. Immune responses to vaccination are largely dependent on three signals107. The most central of these is the signal provided by the antigen (signal 1), which surveys the information required for a specific immune response. Signal 2 derives from the receptor-ligand interaction between APCs and T-cell antigens and is required in order to avoid aborted responses. The activation of APCs and orientation of the TH response depends on signal 0, which is generally triggered through antigen recognition by PRRs.