ADCC definition

ADCC means Antibody Dependent Cellular Cytotoxicity.
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ADCC means antibody-dependent cell-mediated cytotoxicity, which is an immune response, in which an Antibody coats a target-bearing cell and engages Fc receptors on immune effector cells and thereby activates the immune effector cells to lyse the target-bearing cells. For clarity, this is not restricted to effects mediated by natural killer cells, but includes e.g., other effector cells as well.
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ADCC has the meaning set forth in the Preamble.
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Examples of ADCC in a sentence

  • Daratumumab works primarily by directing complement dependent cytotoxicity (CDC) and antibody-dependent cell-mediated cytotoxicity (ADCC) to CD38+ myeloma cells.

  • Tafasitamab incorporates an XmAb(R) engineered Fc domain, which is intended to lead to a significant potentiation of antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), thus aiming to improve a key mechanism of tumor cell killing.

  • In vitro, TRC105 inhibits endothelial cell proliferation, induces endothelial cell apoptosis, and potently engages antibody-dependent cell mediated cytotoxicity (ADCC).

  • The Corporation and ADCC own good, valid and marketable title to the number and percentage of Equity Interests set forth opposite their respective names on Section 3.2(b) of the Disclosure Schedule, free and clear of any and all Liens.

  • In 2015, preclinical data were published in the peer-reviewed journal, Molecular Cancer, that demonstrated that our anti-CAIX antibodies could trigger killing of CAIX-positive human RCC cell lines in tissue culture via ADCC and CDC.

  • This may provide a second mechanism for tumour tissue destruction, by targeting antibody mediated cellular cytotoxicity (ADCC) to the tumour tissue and if conjugated, targeting ionising radiation.

  • The Sellers, the Corporation and ADCC own of record all of the outstanding Equity Interests of the Acquired Companies.

  • Tafasitamab incorporates an XmAb® engineered Fc domain, which is intended to lead to a significant potentiation of antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), thus aiming to improve a key mechanism of tumor cell killing.

  • The evaluation of the ADCC and/or complement effects of an EphA3antibody on normal tissues requires an active isotype version.

  • Ideally, this agent would enhance both the effects of cetuximab (e.g., by augmenting antibody-dependent cellular cytotoxicity; ADCC) and chemotherapy (e.g., by modulating the tumor microenvironment and increasing T cell responses to antigenic debris generated by tumoricidal activity).


More Definitions of ADCC

ADCC. American Diversified Capital Corporation, a California corporation.
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Related to ADCC

  • ADC means antibody-drug conjugate.

  • MSD means the Louisville and Jefferson County Metropolitan Sewer District.

  • NPS means nominal pipe size.

  • ATC means a measure of the transfer capability remaining in the physical transmission network for further commercial activity over and above already committed uses.

  • DS Electric generation service that is provided at retail pursuant to the Applicable Legal Authorities under the Company’s retail electric tariffs and under any other agreements or arrangements between the Company and Customers, to any Customer that is not being served by an EGS. Default Allocation Assessment – shall have the meaning ascribed to it under the PJM Agreements. Delivery Period – The delivery period specified in an Appendix C Transaction Confirmation. Delivery Point – Means the applicable zone of the Company as designated by PJM. DS Customer(s) – Retail customers who are provided Default Service pursuant to the terms of this Agreement, the Applicable Legal Authorities and the Company’s retail tariffs.