4-1BB definition
Examples of 4-1BB in a sentence
Juno Therapeutics has an exclusive license to the St. Jude Children’s Research Hospital patented technology for CD19 directed product candidates that use 4-1BB, which was developed by ▇▇▇▇▇ ▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇ ▇▇▇▇, and St. Jude Children’s Research Hospital.
FFC and FOH have obtained all Permits necessary to use and operate their respective Individual Properties for the use described in Section 4.1(BB).
To the extent a Party engages a CRO to create, develop or use any 4-1BB Bioassay, such Party shall use commercially reasonable efforts to require such CRO to assign to such Party all intellectual property rights covering or comprising such 4-1BB Bioassay.
Arm F2 will consist of the regimen used in arm F1 in combination with utomilumab (4-1BB agonist) as a triplet therapy.
Here, parallel (p)CARs in which a second- generation (CD28+CD3ζ) CAR is co-expressed with a 4-1BB containing chimeric co- stimulatory receptor (CCR), were engineered.
California law further provides that, in the case of a variable board, the maximum number of directors may not exceed two times the minimum number minus one.
Second-generation CARs used in the clinic that utilize either a CD28 or 4-1BB costimulatory module and both have shown impressive outcomes123–125.
A CCR comprising a linear fusion of a CSF-1R leader peptide, 1F5 scFv binding domain (▇▇-▇▇ order), CD8α spacer and transmembrane domain, a 4-1BB co-stimulatory endodomain and FLAG epitope tag was synthesised (“1BB”).
In CARs the most frequently used costimulatory domains derive from the CD28 family (CD28 and ICOS) or the TNFR family (4-1BB, CD27, OX40).
To engineer FBB/Y01-Y05 or G01-G02 pCARs a CCR comprising of a linear fusion of the following elements; a CSF-1R leader peptide, FMC63 scFv binding domain (▇▇-▇▇ order), CD8α spacer and transmembrane domain, a 4-1BB co-stimulatory endodomain and FLAG epitope tag was synthesised (“FBB”).