0001698530-20-000013 Sample Contracts

Innovation and Northwestern University Phone 847-467-2097 Northwestern |INVO New Ventures Office 1800 Sherman Ave, Suite 504 invo.northwestern.edu Innovation and New Ventures Evanston, IL 60201
Exicure, Inc. • March 10th, 2020 • Pharmaceutical preparations

This letter agreement memorializes the understanding reached between Northwestern and Exicure regarding the third amendment to the Agreement ("Amendment Three"). Unless otherwise defined in this Amendment Three, capitalized terms shall have the meaning assigned to them in the Agreement.

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AMENDMENT NO. 4 TO
2011 Restated License Agreement • March 10th, 2020 • Exicure, Inc. • Pharmaceutical preparations

This Amendment No. 4 (this “Amendment”) is entered into as of November 13, 2019 (the “Amendment Effective Date”), by and between Northwestern University, an Illinois not-for-profit corporation with a principal place of business at 633 Clark Street, Evanston, Illinois, 60208 (“Northwestern”), and Exicure, Inc., a Delaware corporation with a principal place of business at 8045 Lamon Avenue, Skokie, Illinois, 60077 (“Exicure”).

COLLABORATION, OPTION AND LICENSE AGREEMENT between EXICURE, INC. and ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED November 13, 2019
Collaboration, Option and License Agreement • March 10th, 2020 • Exicure, Inc. • Pharmaceutical preparations • New York

This COLLABORATION, OPTION AND LICENSE AGREEMENT (this “Agreement”) is entered into as of November 13, 2019 (the “Effective Date”), by and between EXICURE, INC., a Delaware corporation with a place of business at 8045 Lamon Avenue, Suite 410, Skokie, IL 60077 (“Exicure”), and ALLERGAN PHARMACEUTICALS INTERNATIONAL LIMITED, a private company limited by shares, with a place of business at Clonshaugh Business & Technology Park, Dublin 17, D17 E400, Ireland (“Allergan”). In this Agreement, Allergan and Exicure are collectively referred to as the “Parties” and each individually as a “Party”.

Innovation and Northwestern University Phone 847-467-2097 Northwestern |INVO New Ventures Office 1800 Sherman Ave, Suite 504 invo.northwestern.edu Innovation and New Ventures Evanston, IL 60201
Exicure, Inc. • March 10th, 2020 • Pharmaceutical preparations

The following letter memorializes the understanding reached between Northwestern and Exicure regarding the First Amendment to the Agreement ("Amendment One NU Exicure GM3"). Unless otherwise defined In this Agreement, capitalized terms shall have the meaning assigned to them in the Agreement.

Innovation and Northwestern University Phone 847-467-2097 Northwestern |INVO New Ventures Office 1800 Sherman Ave, Suite 504 invo.northwestern.edu Innovation and New Ventures Evanston, IL 60201
Exicure, Inc. • March 10th, 2020 • Pharmaceutical preparations

Re: Amendment One to the License Agreement titled NU Exicure Liposomal Particles License Agreement dated May 27, 2014 ('Agreement") between Exicure, lnc("Exicure") and Northwestern University ("Northwestern').

Innovation and Northwestern University Phone 847-467-2097 Northwestern |INVO New Ventures Office 1800 Sherman Ave, Suite 504 invo.northwestern.edu Innovation and New Ventures Evanston, IL 60201
Exicure, Inc. • March 10th, 2020 • Pharmaceutical preparations

This letter agreement memorializes the understanding reached between Northwestern and Exicure regarding the Second Amendment to the Agreement ("Amendment Two). Unless otherwise defined In this Amendment Two, capitalized terms shall have the meaning assigned to them in the Agreement.

AMENDMENT NO. 2 TO
2014 License Agreement • March 10th, 2020 • Exicure, Inc. • Pharmaceutical preparations

This Amendment No. 2 (this “Amendment”) is entered into as of November 13, 2019 (the “Amendment Effective Date”), by and between Northwestern University, an Illinois not-for-profit corporation with a principal place of business at 633 Clark Street, Evanston, Illinois, 60208 (“Northwestern”), and Exicure, Inc., a Delaware corporation with a principal place of business at 8045 Lamon Avenue, Skokie, Illinois, 60077 (“Exicure”).

Re: Side Agreement to “Northwestern Agreements” in Relation to Allergan Sublicense
Exicure, Inc. • March 10th, 2020 • Pharmaceutical preparations

Reference is hereby made to that certain License Agreement effective as of May 27, 2014, as amended on June 11, 2018, (the “2014 Agreement”), and that certain Restated License Agreement restated on August 15, 2015 and effective as of December 12, 2011, as amended on September 27, 2016, November 30, 2017 and January 1, 2019, (the “2011 Agreement”), in each case, by and between Northwestern University, an Illinois not-for-profit corporation with a principal place of business at 633 Clark Street, Evanston, Illinois, 60208 (“Northwestern”), and Exicure, Inc., a Delaware corporation with a principal place of business at 8045 Lamon Avenue, Skokie, Illinois, 60077 (“Exicure”). The “Northwestern Agreements” means, collectively, the 2011 Agreement and the 2014 Agreement.

AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • March 10th, 2020 • Exicure, Inc. • Pharmaceutical preparations • Illinois

THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (the "Agreement") between Exicure, Inc., a Delaware corporation (the "Company"), and Dr. Matthias Schroff, Ph.D. (the "Executive") (each of the Executive and the Company, a "Party," and collectively, the "Parties"), amends and restates in its entirety the Employment Agreement between the Company and Executive entered into as of January 18, 2018. This Agreement is effective as of December 10, 2019 (the "Effective Date").

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