0001683168-19-001995 Sample Contracts

SECOND AMENDMENT TO SHARE PURCHASE AGREEMENT
Share Purchase Agreement • June 24th, 2019 • Xenetic Biosciences, Inc. • Pharmaceutical preparations • Delaware

THIS SECOND AMENDMENT TO SHARE PURCHASE AGREEMENT (this “Amendment”), dated June 24, 2019, is entered into by and between Xenetic Biosciences, Inc., a Nevada corporation (“Buyer”) and Alexey Andreevich Vinogradov, as the representative of each Seller as more fully described in the Purchase Agreement (as defined below) (the “Sellers’ Representative”).

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SECOND AMENDMENT TO ASSIGNMENT AGREEMENT
Assignment Agreement • June 24th, 2019 • Xenetic Biosciences, Inc. • Pharmaceutical preparations • Delaware

THIS SECOND AMENDMENT TO ASSIGNMENT AGREEMENT (this “Amendment”), dated June 24, 2019, is entered into by and between Xenetic Biosciences, Inc., a Nevada corporation (“Buyer”), and OPKO PHARMACEUTICALS, LLC (“OPKO”).

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