0001628280-19-006483 Sample Contracts

SECOND AMENDED & RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • May 10th, 2019 • Regulus Therapeutics Inc. • Pharmaceutical preparations • California

This SECOND AMENDED & RESTATED EMPLOYMENT AGREEMENT (the “Agreement”) is made and entered into effective as of July 24, 2018 (the “Effective Date”), by and between REGULUS THERAPEUTICS INC., a Delaware corporation (the “Company”), and CHRISTOPHER AKER (the “Executive”). The Company and the Executive are hereinafter collectively referred to as the “Parties”, and individually referred to as a “Party”.

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SEVENTH AMENDMENT TO THE LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • May 10th, 2019 • Regulus Therapeutics Inc. • Pharmaceutical preparations • California

THIS SEVENTH AMENDMENT TO THE LOAN AND SECURITY AGREEMENT (this “Amendment”) is made effective as of April 9, 2019 (the “Seventh Amendment Date”) by and among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 133 North Fairfax Street, Alexandria, Virginia 22314 (in its individual capacity, “Oxford”; and in its capacity as Collateral Agent, “Collateral Agent”), the Lenders listed on Schedule 1.1 of the Loan Agreement (as defined below) from time to time including Oxford in its capacity as a Lender (each a “Lender” and collectively, the “Lenders”) and REGULUS THERAPEUTICS INC., a Delaware corporation with offices located at 10614 Science Center Dr., San Diego, California 92121 (“Borrower”).

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