0001564590-21-007292 Sample Contracts

AMENDED AND RESTATED LOAN AGREEMENT Dated as of November 3, 2020
Loan Agreement • February 23rd, 2021 • Epizyme, Inc. • Pharmaceutical preparations • New York

THIS AMENDED AND RESTATED LOAN AGREEMENT (this “Agreement”), dated as of November 3, 2020 (the “Effective Date”) by and among EPIZYME, INC., a Delaware corporation (as “Borrower”), BIOPHARMA CREDIT PLC, a public limited company incorporated under the laws of England and Wales (as the “Collateral Agent”), BPCR LIMITED PARTNERSHIP, a limited partnership formed under the laws of England (as a “Lender”) and BIOPHARMA CREDIT INVESTMENTS V (MASTER) LP, a Cayman Islands exempted limited partnership (as a “Lender”), provides the terms on which each Lender shall make, and Borrower shall repay, the Credit Extensions (as hereinafter defined). Borrower, the Collateral Agent and BioPharma Credit Investments V (Master) LP are party to that certain Loan Agreement (the “Original Loan Agreement”), dated as of November 4, 2019 (the “Execution Date”). Borrower has requested that Lenders make available to Borrower the Tranche D Loan (as hereinafter defined) and, in connection with Lenders’ agreement to pr

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AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT by and between EISAI CO., LTD. and EPIZYME, INC.
Collaboration and License Agreement • February 23rd, 2021 • Epizyme, Inc. • Pharmaceutical preparations • New York

This AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT (this “Agreement”) is entered into and made effective as of the 12th day of March, 2015 (the “Restatement Date”) by and between Epizyme, Inc., a Delaware corporation having its principal place of business at 400 Technology Square, 4th Floor, Cambridge, Massachusetts 02139, U.S.A. (“EPIZYME”), and Eisai Co., Ltd., a Japan corporation, having its principal place of business at Koishikawa 4-6-10, Bunkyo-Ku, Tokyo 112-8088, Japan (“EISAI”). EPIZYME and EISAI are each referred to herein by name or as a “Party” or, collectively, as the “Parties.”

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