0001564590-21-001139 Sample Contracts

Re: Employment Agreement
Xenon Pharmaceuticals Inc. • January 14th, 2021 • Pharmaceutical preparations • British Columbia

Further to your discussion with the Board to transition from the Chief Executive Officer role, we are pleased to offer you the position of Executive Chair of the Board of Directors, from the Company’s 2021 annual meeting of shareholders expected to take place on or about June 4, 2021 (the “Effective Date”) to the Company’s 2022 annual meeting of shareholders expected to take place in June 2022 (the “End Date”) (from the Effective Date to the End Date, the “Term”), on the terms and conditions set forth in this Employment Agreement. Unless previously terminated in accordance with Section M, N, O or P or extended by mutual written agreement, your employment with the Company will automatically end as of the End Date. Please note that this new Employment Agreement will replace and supersede any earlier Employment Agreements you may have had with the Company as of the Effective Date.

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Contract
Xenon Pharmaceuticals Inc. • January 14th, 2021 • Pharmaceutical preparations

CERTAIN INFORMATION HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE IT IS BOTH NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE REGISTRANT IF PUBLICLY DISCLOSED. OMISSIONS ARE DESIGNATED AS [†].

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