0001564590-20-009385 Sample Contracts

Re: Amended and Restated Employment Agreement
Prior Agreement • March 9th, 2020 • Xenon Pharmaceuticals Inc. • Pharmaceutical preparations • Massachusetts

We are pleased to offer you this Amended and Restated Employment Agreement which replaces and supersedes your earlier Offer of Employment (the “Prior Agreement”) dated January 1, 2017 with Xenon Pharmaceuticals USA Inc. (the “Company”), a wholly-owned subsidiary of Xenon Pharmaceuticals Inc. (the “Parent”). You will be credited for all purposes with your service to the Company back to your start date of February 8, 2016, when you were originally employed by Parent. As of March 20, 2019 (the “Effective Date”), you will continue to be engaged by the Company in the full-time position of SVP, Drug Discovery. Subject to Sections L through P below, the Company agrees to employ you, and you agree to serve the Company, on an “at-will” basis, which means that either the Company or you may terminate your employment with the Company at any time and for any or no reason, in accordance with the terms of this agreement (the “Agreement”).

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Re: Amended and Restated Employment Agreement
Employment Agreement • March 9th, 2020 • Xenon Pharmaceuticals Inc. • Pharmaceutical preparations • British Columbia

We are pleased to offer you this Amended and Restated Employment Agreement which replaces and supersedes your earlier Employment Agreement. You will be credited for all purposes with your service to the Company back to your start date of May 1, 2001. As of March 19, 2019 (the “Effective Date”), you will continue to be engaged by the Company in the full-time position of Executive Vice President, Strategy & Innovation.

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