0001564590-14-005554 Sample Contracts

SECOND AMENDMENT TO CLINICAL TRIAL COLLABORATION AGREEMENT
Trial Collaboration Agreement • November 12th, 2014 • ARCA Biopharma, Inc. • In vitro & in vivo diagnostic substances

This Second Amendment to Clinical Trial Collaboration Agreement (this “Amendment”) is made and entered into as of August 28, 2014 (the “Amendment Effective Date”) and amends the Clinical Trial Collaboration Agreement dated April 18, 2013, as amended effective June 15, 2014 (“Agreement”) between ARCA biopharma, Inc., a Delaware corporation (hereinafter “ARCA”), and Medtronic, Inc., a Delaware corporation (hereinafter “Medtronic”) (collectively, the “Parties”).

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