0001558370-23-013057 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • August 3rd, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations • New York

This Employment Agreement (the “Agreement”) is entered into effective as of June 22, 2023_____ (the “Effective Date”), by and between Alethia Young (“Executive”) and Bicycle Therapeutics Inc. (the “Company”).

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THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • August 3rd, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations • California

of May 15, 2023, is entered into by and among BICYCLE THERAPEUTICS PLC, a public limited company organized under the laws of England and Wales (“Parent”), BICYCLETX LIMITED, a private company limited by shares organized under the laws of England and Wales (“BicycleTx”), BICYCLERD LIMITED, a private company limited by shares organized under the laws of England and Wales (“BicycleRD”), BICYCLE THERAPEUTICS INC., a Delaware corporation (“Bicycle US”) and each of Parent’s Subsidiaries that delivers a Joinder Agreement pursuant to Section 7.13 of the Loan Agreement (hereinafter collectively referred to as “Borrowers” and each, “Borrower”), the several banks and other financial institutions or entities from time to time parties to the Loan Agreement (as defined below) (collectively, referred to as the “Lenders”) and HERCULES CAPITAL, INC., a Maryland corporation, in its capacity as administrative agent and collateral agent for the Lenders (in such capacity, “Agent”).

AMENDMENT NO. 3 TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • August 3rd, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations

This Amendment No. 3 to Collaboration and License Agreement (“Third Amendment”) is made and entered into effective as of 27th April 2023 (“Third Amendment Effective Date”) by and between BicycleTx Limited, a company incorporated in England and Wales with a place of business at Blocks A & B, Portway Building Granta Park, Great Abington, Cambridge, United Kingdom, CB21 6GS (“BicycleTx”), and Ionis Pharmaceuticals, Inc., a Delaware corporation with a principal place of business at 2855 Gazelle Court, Carlsbad, California 92010, USA (“Ionis”).

Contract
Collaboration and Licence Agreement • August 3rd, 2023 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED.

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