0001558370-23-001465 Sample Contracts

NON-QUALIFIED STOCK OPTION AGREEMENT FOR NON-EMPLOYEE DIRECTORS UNDER THE BLUEPRINT MEDICINES CORPORATION
Non-Qualified Stock Option Agreement • February 16th, 2023 • Blueprint Medicines Corp • Pharmaceutical preparations • Delaware

Name of Optionee: %%FIRST_NAME%-% %%LAST_NAME%-% ​ ​ No. of Option Shares: %%TOTAL_SHARES_GRANTED,'999,999,999'%-% ​ ​ Option Exercise Price per Share: %%OPTION_PRICE%-% ​ ​ Grant Date: %%OPTION_DATE%-% ​ ​ Expiration Date: %%EXPIRE_DATE_PERIOD1%-%

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RESTRICTED STOCK UNIT AWARD AGREEMENT FOR EMPLOYEES UNDER THE BLUEPRINT MEDICINES CORPORATION
Restricted Stock Unit Award Agreement • February 16th, 2023 • Blueprint Medicines Corp • Pharmaceutical preparations • Delaware

Pursuant to the Blueprint Medicines Corporation 2015 Stock Option and Incentive Plan as amended through the date hereof (the “Plan”), Blueprint Medicines Corporation (the “Company”) hereby grants an award of the number of Restricted Stock Units listed above (an “Award”) to the Grantee named above subject to the terms and conditions in this Restricted Stock Unit Award Agreement, including the Privacy Notice attached hereto as Exhibit A, the General Terms and Conditions for Non-U.S. Grantees attached hereto as Exhibit B and any Country-Specific Terms and Conditions for the Grantee’s country attached hereto as Exhibit C (collectively, the “Agreement”), and in the Plan. Each Restricted Stock Unit shall relate to one share of Common Stock, par value $0.001 per share, of the Company (the “Stock”).

THIRD AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • February 16th, 2023 • Blueprint Medicines Corp • Pharmaceutical preparations

This Third Amendment to Employment Agreement (this “Third Amendment”) between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Chris Murray (the “Executive”), is effective as of January 1, 2023 (the “Third Amendment Effective Date”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

NON-QUALIFIED STOCK OPTION AGREEMENT UNDER THE BLUEPRINT MEDICINES CORPORATION
Non-Qualified Stock Option Agreement • February 16th, 2023 • Blueprint Medicines Corp • Pharmaceutical preparations • Delaware

​ ​ ​ Name of Optionee: %%FIRST_NAME%-% %%LAST_NAME%-% ​ ​ ​ No. of Option Shares: ​ %%TOTAL_SHARES_GRANTED,'999,999,999'%-% ​ ​ ​ Option Exercise Price per Share: ​ %%OPTION_PRICE%-% ​ ​ ​ Vesting Start Date: ​ %%VEST_BASE_DATE%-% ​ ​ ​ Grant Date: ​ %%OPTION_DATE%-% ​ ​ ​ Expiration Date: ​ %%EXPIRE_DATE_PERIOD1%-%

THIRD AMENDMENT TO EMPLOYMENT AGREEMENT
Employment Agreement • February 16th, 2023 • Blueprint Medicines Corp • Pharmaceutical preparations

This Third Amendment to Employment Agreement (this “Third Amendment”) between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Ariel Hurley (the “Executive”), is effective as of January 1, 2023 (the “Third Amendment Effective Date”). Capitalized terms used and not defined herein shall have the meanings ascribed to such terms in the Employment Agreement (as defined below).

PERFORMANCE-BASED RESTRICTED STOCK UNIT AWARD AGREEMENT FOR EMPLOYEES UNDER THE BLUEPRINT MEDICINES CORPORATION
Award Agreement for Employees • February 16th, 2023 • Blueprint Medicines Corp • Pharmaceutical preparations • Delaware

Pursuant to the Blueprint Medicines Corporation 2015 Stock Option and Incentive Plan as amended through the date hereof (the “Plan”), Blueprint Medicines Corporation (the “Company”) hereby grants an award of the target number of PSUs listed above (an “Award”) to the Grantee named above subject to the terms and conditions in this Performance-Based Restricted Stock Unit Award Agreement, including the Performance Multiplier for Performance Cycle attached hereto as Exhibit A, the Privacy Notice attached hereto as Exhibit B, the General Terms and Conditions for Non-U.S. Grantees attached hereto as Exhibit C and any Country-Specific Terms and Conditions for the Grantee’s country attached hereto as Exhibit D (collectively, the “Agreement”), and in the Plan. Each PSU shall relate to one share of Common Stock, par value $0.001 per share, of the Company (the “Stock”).

RESTRICTED STOCK UNIT AWARD AGREEMENT UNDER THE BLUEPRINT MEDICINES CORPORATION
Restricted Stock Unit Award Agreement • February 16th, 2023 • Blueprint Medicines Corp • Pharmaceutical preparations • Delaware

Pursuant to the Blueprint Medicines Corporation 2020 Inducement Plan as amended through the date hereof (the “Plan”), Blueprint Medicines Corporation (the “Company”) hereby grants an award of the number of Restricted Stock Units listed above (an “Award”) to the Grantee named above, subject to the terms and conditions set forth in this Restricted Stock Unit Award Agreement, including the Privacy Notice attached hereto as Exhibit A (the “Agreement”) and in the Plan. Each Restricted Stock Unit shall relate to one share of Common Stock, par value $0.001 per share, of the Company (the “Stock”). For the avoidance of doubt, this Award is not issued under the Company’s 2015 Stock Option and Incentive Plan, as amended from time to time, and does not reduce the share reserve under such equity plan. This Award has been granted as an inducement pursuant to Rule 5635(c)(4) of the Marketplace Rules of The Nasdaq Stock Market LLC.

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