0001558370-22-016140 Sample Contracts

AMENDMENT NO. 2 TO COLLABORATION AND LICENSE AGREEMENT
Collaboration and License Agreement • November 3rd, 2022 • BICYCLE THERAPEUTICS PLC • Pharmaceutical preparations • New York

THIS AMENDMENT NO. 2 TO COLLABORATION AND LICENSE AGREEMENT (“Second Amendment”) is made and entered into effective as of July 28, 2022 (“Second Amendment Effective Date”) by and between BicycleTx Limited, a company incorporated in England and Wales with a place of business at Blocks A & B Portway Building, Granta Park, Great Abington, Cambridge, CB21 6GS (“BicycleTx”), and Ionis Pharmaceuticals, Inc., a Delaware corporation with a principal place of business at 2855 Gazelle Court, Carlsbad, California 92010, USA (“Ionis”).

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