0001558370-19-002525 Sample Contracts

LICENSE AGREEMENT N° 09533C10 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO...
License Agreement • March 28th, 2019 • ProQR Therapeutics N.V. • Pharmaceutical preparations

This License Agreement (the “Agreement”) is made as of its last date of signature by all signatories (the “Effective Date”) by and between:

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SHARE PURCHASE AGREEMENT By and Between IONIS PHARMACEUTICALS, INC. AND PROQR THERAPEUTICS N.V. Dated as of October 26, 2018
Share Purchase Agreement • March 28th, 2019 • ProQR Therapeutics N.V. • Pharmaceutical preparations • New York

THIS SHARE PURCHASE AGREEMENT (this “Agreement”), dated as of October 26, 2018 (the “Execution Date”), by and between Ionis Pharmaceuticals, Inc. (the “Investor”), a Delaware corporation, and ProQR Therapeutics N.V. (the “Company”), a public company with limited liability incorporated under the laws of the Netherlands.

LICENSE AGREEMENT between Ionis Pharmaceuticals, Inc. and ProQR Therapeutics IV B.V.
License Agreement • March 28th, 2019 • ProQR Therapeutics N.V. • Pharmaceutical preparations • Delaware

CONFIDENTIAL TREATMENT REQUESTED. CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKED, IS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

INVESTOR AGREEMENT
Investor Agreement • March 28th, 2019 • ProQR Therapeutics N.V. • Pharmaceutical preparations • New York

THIS INVESTOR AGREEMENT (this “Agreement”) is made as of October 26, 2018, by and between Ionis Pharmaceuticals, Inc. (the “Investor”), a Delaware corporation, and ProQR Therapeutics N.V. (the “Company”), a public company with limited liability incorporated under the laws of the Netherlands.

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