0001544227-18-000004 Sample Contracts

Nonstatutory Stock Option Agreement
Stock Option Agreement • May 3rd, 2018 • OvaScience, Inc. • Pharmaceutical preparations • Delaware
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Waltham, Massachusetts 02451 RE: Termination of Advisory Agreement Dear Michelle:
OvaScience, Inc. • May 3rd, 2018 • Pharmaceutical preparations

You and OvaScience, Inc. (the “Company”) are parties to that certain Advisory Agreement governing your advisory services to the Company dated June 21, 2017 (as amended August 3, 2017) (the “Advisory Agreement”). We have agreed to terminate the Advisory Agreement in accordance with the terms set forth herein.

Amendment No. 1 To The Exclusive License Agreement
Confidential Treatment • May 3rd, 2018 • OvaScience, Inc. • Pharmaceutical preparations • Massachusetts

This Amendment No. 1 (this “Amendment”) to the Exclusive License Agreement between OvaScience, Inc. (“Company”) and The General Hospital Corporation, (“Hospital”) dated June 27, 2011 (the “Agreement”), is effective as of September 7, 2011. Capitalized terms used but not defined in this Amendment shall, unless the context otherwise requires, have the meanings specified in the Agreement.

THE GENERAL HOSPITAL CORPORATION EXCLUSIVE LICENSE AGREEMENT MGH Agreement No: A209968 MGH Case Nos: 02595 and 21131
Exclusive License Agreement • May 3rd, 2018 • OvaScience, Inc. • Pharmaceutical preparations • Massachusetts

This Exclusive License Agreement (“Agreement”) is made as of the 27th day of June, 2011 (“Effective Date”), by and between OvaScience, Inc., a Delaware corporation, having a principal place of business at The Prudential Tower, 800 Boylston Street, Suite 1555, Boston, MA 02199 (“Company”) and The General Hospital Corporation, d/b/a Massachusetts General Hospital, a not-for-profit Massachusetts corporation, with a principal place of business at 55 Fruit Street, Boston, Massachusetts 02114 (“Hospital”), each referred to herein individually as a “Party” and collectively as the “Parties”.

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