0001403752-21-000020 Sample Contracts

SECOND AMENDMENT TO LICENSE AND COLLABORATION AGREEMENT
License and Collaboration Agreement • November 3rd, 2021 • Zymeworks Inc. • Pharmaceutical preparations • New York

This Second Amendment (the “Amendment”) to the Agreement (as defined below), is entered into as of August 10, 2021 (the “Amendment Effective Date”), by and between Zymeworks Inc., a corporation organized and existing under the laws of British Columbia (“Zymeworks”), having a place of business at 540-1385 West 8th Avenue, Vancouver, BC, Canada V6H 3V9, and Beigene, Ltd., a Cayman Island exempted company incorporated with limited liability (“BeiGene”), having a place of business at c/o Mourant Governance Services (Cayman) Limited, 94 Solaris Avenue, Camana Bay, PO Box 1348, Grand Cayman KY1-1108, Cayman Islands. Zymeworks and BeiGene are each referred to individually as a “Party” and together as the “Parties”.

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FOURTH AMENDMENT TO COLLABORATION AGREEMENT
Collaboration Agreement • November 3rd, 2021 • Zymeworks Inc. • Pharmaceutical preparations • New York

This Fourth Amendment (the “Amendment”) to the Agreement (as defined below), is entered into as of August 4, 2021 (the “Amendment Effective Date”), by and between CELGENE CORPORATION, a corporation organized and existing under the laws of Delaware, with its principal business office located at 86 Morris Avenue, Summit, NJ 07901, USA (“Celgene Corp.”), CELGENE ALPINE INVESTMENT CO. LLC (“Celgene Alpine” and, together with Celgene Corp., “Celgene”) and ZYMEWORKS INC., a corporation organized and existing under the laws of British Columbia, having an address at 540-1385 West 8th Avenue, Vancouver, BC, Canada V6H 3V9 (“Zymeworks”). Zymeworks and Celgene are each referred to individually as a “Party” and together as the “Parties”.

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