0001403752-21-000015 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • August 4th, 2021 • Zymeworks Inc. • Pharmaceutical preparations • Washington

ZYMEWORKS BIOPHARMACEUTIALS INC., a corporation registered in the State of Washington and having its principal place of business at 350-2400 3rd Avenue, Seattle, WA, 98121, USA

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SECOND AMENDMENT TO COLLABORATION AND CROSS LICENSE AGREEMENT
Collaboration and Cross License Agreement • August 4th, 2021 • Zymeworks Inc. • Pharmaceutical preparations • New York

This Second Amendment (the “2nd Amendment”) to that certain Collaboration and Cross License Agreement, dated September 26, 2016, as amended pursuant to a Side Letter Agreement dated effective September 25, 2018 (collectively, the “Agreement”) by and between DAIICHI SANKYO COMPANY, LIMITED, a corporation organized and existing under the laws of Japan, with its principal business office located at 3-5-1, Nihonbashi honcho, Chuo-ku, Tokyo 103-8426, Japan (“DS”) and ZYMEWORKS INC., a corporation organized and existing under the laws of British Columbia, having an address at 540-1385 West 8th Avenue, Vancouver, BC, Canada V6H 3V9 (“Zymeworks”), is entered into as of July 2, 2021 (“2nd Amendment Effective Date”). Zymeworks and DS are each referred to individually as a “Party” and together as the “Parties.”

FOURTH LEASE MODIFICATION AGREEMENT
Fourth Lease Modification Agreement • August 4th, 2021 • Zymeworks Inc. • Pharmaceutical preparations
SECOND AMENDMENT TO COLLABORATION AGREEMENT
Collaboration Agreement • August 4th, 2021 • Zymeworks Inc. • Pharmaceutical preparations • New York

This Second Amendment (the “Amendment”) to the Agreement (as defined below), is entered into as of June 2, 2021 (the “Second Amendment Effective Date”), by and between Zymeworks Inc., a corporation organized and existing under the laws of British Columbia (“Zymeworks”), having a place of business at 540-1385 West 8th Avenue, Vancouver, BC, Canada V6H 3V9, and Beigene, Ltd., a Cayman Island exempted company incorporated with limited liability (“BeiGene”), having a place of business at c/o Mourant Governance Services (Cayman) Limited, 94 Solaris Avenue, Camana Bay, PO Box 1348, Grand Cayman KY1-1108, Cayman Islands. Zymeworks and BeiGene are each referred to individually as a “Party” and together as the “Parties”.

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