0001362310-08-007271 Sample Contracts

FOURTH AMENDMENT TO AMENDED AND RESTATED STRATEGIC ALLIANCE AGREEMENT (NICOTINIC ALPHA-7 PROGRAM)
Strategic Alliance Agreement • November 14th, 2008 • Memory Pharmaceuticals Corp • Pharmaceutical preparations

This FOURTH AMENDMENT TO AMENDED AND RESTATED STRATEGIC ALLIANCE AGREEMENT (NICOTINIC ALPHA-7 PROGRAM) (this “Amendment”) is effective as of the 15th day of July, 2008, by and among Memory Pharmaceuticals Corp. (“Memory”), and F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc. (together, “Roche”).

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Memory Pharmaceuticals Corp. 100 Philips Parkway Montvale, New Jersey 07645 Phone: (201) 802-7100 Fax: (201) 802-7190 www.memorypharma.com September 29, 2008 Mr. James R. Sulat Dear Jim:
Memory Pharmaceuticals Corp • November 14th, 2008 • Pharmaceutical preparations • New Jersey

This letter reflects the change in your position with Memory Pharmaceuticals Corp. (the “Company”), effective February 7, 2008 (the “Effective Date”) and shall be effective as of the Effective Date. This agreement (other than Section 5 (“Indemnification”) and 6 (“Confidentiality”) shall expire on December 31, 2009, unless extended by mutual agreement between you and the Company or terminated earlier, pursuant to section 2, below, provided that the Company shall be obligated to make any payment required under Section 3(c) after this agreement expires if such obligation arises on account of a separation from service that occurs before the agreement expires.

FIFTH AMENDMENT TO AMENDED AND RESTATED STRATEGIC ALLIANCE AGREEMENT (NICOTINIC ALPHA-7 PROGRAM)
Strategic Alliance Agreement • November 14th, 2008 • Memory Pharmaceuticals Corp • Pharmaceutical preparations

This FIFTH AMENDMENT TO AMENDED AND RESTATED STRATEGIC ALLIANCE AGREEMENT (NICOTINIC ALPHA-7 PROGRAM) (this “Amendment” or the “Fifth Amendment”) is executed to be effective this 15th day of September, 2008, by and among F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc. (together, “Roche”), and Memory Pharmaceuticals Corp. (“Memory”).

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