0001341004-17-000445 Sample Contracts

FIRST AMENDMENT TO COLLABORATION AGREEMENT
Collaboration Agreement • July 18th, 2017 • Zymeworks Inc. • Pharmaceutical preparations • New York

This First Amendment (the "Amendment") to the Agreement (as defined below), is entered into as of May 29, 2017, by and between CELGENE CORPORATION, a corporation organized and existing under the laws of Delaware, with its principal business office located at 86 Morris Avenue, Summit, NJ 07901, USA ("Celgene Corp."), CELGENE ALPINE INVESTMENT CO. LLC ("Celgene Alpine" and, together with Celgene Corp., "Celgene") and ZYMEWORKS INC., a corporation organized and existing under the laws of Canada, and extra provincially in British Columbia, having an address at 540-1385 West 8th Avenue, Vancouver, BC, Canada V6H 3V9 ("Zymeworks"). Zymeworks and Celgene are each referred to individually as a "Party" and together as the "Parties".

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