0001299933-08-000854 Sample Contracts

NINTH AMENDMENT TO CONSULTING AGREEMENT
Consulting Agreement • February 19th, 2008 • Encysive Pharmaceuticals Inc • Pharmaceutical preparations

This NINTH AMENDMENT TO CONSULTING AGREEMENT (the “Amendment”) is entered into on February 15, 2008, to be effective as of January 1, 2008 (the “Effective Date”), by and between JOHN M. PIETRUSKI, an individual residing at 27 Paddock Lane, Colts Neck, New Jersey 07722 (“Consultant”), and ENCYSIVE PHARMACEUTICALS INC., a Delaware corporation located at 4848 Loop Central Drive, Suite 700, Houston, Texas 77081 (the “Corporation”).

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