0001275287-05-001929 Sample Contracts

ARRANGEMENT AGREEMENT
Arrangement Agreement • May 16th, 2005 • Isotis Sa • Services-commercial physical & biological research • British Columbia

WHEREAS GenSci intends to propose to its shareholders an arrangement under Section 252 of the Company Act on the terms of the Plan of Arrangement annexed hereto as Schedule A;

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IsoTis Letter Agreement
Letter Agreement • May 16th, 2005 • Isotis Sa • Services-commercial physical & biological research

You hereby agree to terminate and waive all claims under your employment agreement dated January 1, 2003 with GenSci OrthoBiologics Inc., GenSci Regeneration Sciences Inc. and GenSci OCF, Inc. (“Employment Agreement”). In consideration thereof, IsoTis shall pay you the sum of USD $180,000.

AGREEMENT between
Agreement • May 16th, 2005 • Isotis Sa • Services-commercial physical & biological research

The Employee and IsoTis, by common accord, agree to terminate the work relationship between both parties effective March 31, 2005 pursuant to the covenants given in this Agreement.

SHARE PURCHASE AGREEMENT regarding CHIENNA B.V. between IsoTis N.V. and Octoshare B.V.
Share Purchase Agreement • May 16th, 2005 • Isotis Sa • Services-commercial physical & biological research
TERMINATION AGREEMENT between
Termination Agreement • May 16th, 2005 • Isotis Sa • Services-commercial physical & biological research

By his signature on this Agreement, Mr. Essinger confirms that he is resigning with immediate effect of all functions which he is exercising for ISOTIS and all its subsidiaries and affiliated companies. He undertakes that he will sign all the necessary documents and fully cooperate with ISOTIS and the other Companies concerned in order to take the necessary steps for registering his resignation.

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