0001206774-04-000794 Sample Contracts

June 1, 2004
Avigen Inc \De • August 9th, 2004 • In vitro & in vivo diagnostic substances

This letter amendment (this “Amendment”) is to confirm the changes agreed upon between WELLS FARGO BANK, NATIONAL ASSOCIATION (“Bank”) and Avigen, Inc. (“Borrower”) to the terms and conditions of that certain letter agreement between Bank and Borrower dated as of November 2, 2000, as amended from time to time (the “Agreement”). For valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Bank and Borrower hereby agree that the Agreement shall be amended as follows to reflect said changes.

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