0001193805-21-000363 Sample Contracts

Contract
Deposit Agreement • March 15th, 2021 • JPMorgan Chase Bank, N.A. - ADR Depositary • American depositary receipts • New York

AMENDMENT NO. 1 dated as of , 2021 (the "Amendment"), to the Second Amended and Restated Deposit Agreement dated as of July 29, 2019 (the "Deposit Agreement"), among GlaxoSmithKline plc, incorporated under the laws of England and Wales (the "Company"), JPMorgan Chase Bank, N.A., as depositary (the "Depositary"), and all Holders and Beneficial Owners from time to time of American depositary receipts ("ADRs") issued thereunder.

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