0001193805-16-003200 Sample Contracts

ASTRAZENECA PLC AND CITIBANK, N.A., As Depositary, AND ALL HOLDERS AND BENEFICIAL OWNERS OF AMERICAN DEPOSITARY SHARES OUTSTANDING UNDER THE TERMS OF THE AMENDED AND RESTATED DEPOSIT AGREEMENT, DATED AS OF FEBRUARY 6, 2015
Deposit Agreement • May 9th, 2016 • Citibank,N.A./ADR • Pharmaceutical preparations • New York

AMENDMENT NO. 1 TO AMENDED AND RESTATED DEPOSIT AGREEMENT dated as of July 27, 2015 (the “Amendment”), by and among ASTRAZENECA PLC, a company incorporated in England (the “Company”), Citibank, N.A., a national banking association organized under the laws of the United States of America (the “Depositary”), and all Holders and Beneficial Owners from time to time of American Depositary Receipts outstanding under the Amended and Restated Deposit Agreement, dated as of February 6, 2015.

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