0001193805-07-002995 Sample Contracts

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AND CITIBANK, N.A., As Depositary AND
Deposit Agreement • November 28th, 2007 • Amarin Corp Plc\uk • Pharmaceutical preparations
AMARIN CORPORATION PLC 7 CURZON STREET LONDON W1J 5HG
Supplemental Letter Agreement • November 28th, 2007 • Amarin Corp Plc\uk • Pharmaceutical preparations • New York

Reference is made to (i) the Deposit Agreement, dated as of March 29, 1993, as amended by Amendment No. 1 to Deposit Agreement, dated as of October 8, 1998, and as further amended by Amendment No. 2 to Deposit Agreement, dated as of September 25, 2002 (the Deposit Agreement as amended by Amendment No. 1 to Deposit Agreement and Amendment No. 2 to Deposit Agreement, the "Deposit Agreement"), by and among Amarin Corporation plc (formerly known as "Ethical Holdings plc"), a corporation organized and existing under the laws of England and Wales (the "Company"), Citibank, N.A., as Depositary (the "Depositary"), and all Holders from time to time of American Depositary Receipts ("ADRs") evidencing American Depositary Shares ("ADSs") issued thereunder and (ii) the letter agreement, dated as of March 29, 2006 (the "Letter Agreement"), between the Company and the Depositary relating to the issuance of Restricted ADSs (as defined in the Letter Agreement). Capitalized terms used but not defined he

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