0001193125-26-352229 Sample Contracts

OPEN MARKET SALE AGREEMENT1
Open Market Sale Agreement • August 14th, 2026 • Achieve Life Sciences, Inc. • In vitro & in vivo diagnostic substances • New York

Achieve Life Sciences, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent (the “Agent”), shares of the Company’s common stock, par value $0.001 per share (the “Common Shares”), on the terms set forth in this agreement (this “Agreement”).