0001193125-25-272592 Sample Contracts

GUARDANT HEALTH, INC. and U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION as Trustee INDENTURE Dated as of November 7, 2025 0% Convertible Senior Notes due 2033
Indenture • November 7th, 2025 • Guardant Health, Inc. • Services-medical laboratories • New York

INDENTURE, dated as of November 7, 2025, between Guardant Health, Inc., a Delaware corporation, as issuer (the “Company”), and U.S. Bank Trust Company, National Association, as trustee (the “Trustee”).

GUARDANT HEALTH, INC. 3,333,333 Shares of Common Stock, par value $0.00001 per share Underwriting Agreement
Underwriting Agreement • November 7th, 2025 • Guardant Health, Inc. • Services-medical laboratories • New York

Guardant Health, Inc., a Delaware corporation (the “Company”), proposes to issue and sell to the several underwriters listed in Schedule 1 hereto (the “Underwriters”), for whom you are acting as representatives (the “Representatives”), an aggregate of 3,333,333 shares of common stock, par value $0.00001 per share (“Common Stock”), of the Company (the “Underwritten Shares”). In addition, the Company proposes to issue and sell, at the option of the Underwriters, up to an additional 499,999 shares of Common Stock (the “Option Shares”). The Underwritten Shares and the Option Shares are herein referred to as the “Shares”. The shares of Common Stock of the Company to be outstanding after giving effect to the sale of the Shares are referred to herein as the “Stock”.