0001193125-25-145742 Sample Contracts

NOTE EXCHANGE AND WARRANT PURCHASE AGREEMENT
Note Exchange and Warrant Purchase Agreement • June 24th, 2025 • Jaguar Health, Inc. • Pharmaceutical preparations • New York

THIS NOTE EXCHANGE AND WARRANT PURCHASE AGREEMENT (this “Agreement”), dated as of June 23, 2025 (the “Execution Date”), is entered into by and between JAGUAR HEALTH, INC., a Delaware corporation, (the “Company”), and the purchaser identified on the signature pages hereto (including its successors and assigns, the “Participating Buyer”).

COMMON STOCK PURCHASE WARRANT JAGUAR HEALTH, INC.
Security Agreement • June 24th, 2025 • Jaguar Health, Inc. • Pharmaceutical preparations • New York

This COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, the Holder (as defined below)), [.] (including any permitted and registered assigns, the “Holder”), is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date of issuance hereof, to purchase from Jaguar Health, Inc., a Delaware corporation (the “Company”), up to [.] shares of Common Stock (as defined below) (the “Warrant Shares”) (whereby such number may be adjusted from time to time pursuant to the terms and conditions of this Warrant) at the Exercise Price (as defined below) per share then in effect. This Warrant is issued by the Company as of the Issuance Date in connection with that certain Note Exchange and Warrant Purchase Agreement, dated as of [ ], 2025, by and between the Company and the Holder (as amended, restated, supplemented or otherwise modified from time to time, the “Exchange Agreement”).