0001193125-24-023462 Sample Contracts

INDEMNIFICATION AGREEMENT
Indemnification Agreement • February 5th, 2024 • Spyre Therapeutics, Inc. • Pharmaceutical preparations

This Indemnification Agreement (this “Agreement”) is entered into as of by and between Spyre Therapeutics, Inc., a Delaware corporation (the “Company”), and (the “Indemnitee”) and shall be deemed effective upon the earliest date that the Indemnitee is duly elected or appointed as a director or officer of the Company.

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February 1, 2024 Cameron Turtle Re: Amendment to Amended and Restated Employment Letter Agreement Dear Cameron:
Letter Agreement • February 5th, 2024 • Spyre Therapeutics, Inc. • Pharmaceutical preparations • Washington

This letter, effective as of the date first set forth above (this “Amendment”), amends that certain amended and restated employment letter agreement between you and Spyre Therapeutics, Inc. (f/k/a Aeglea BioTherapeutics, Inc.) (the “Company”) dated November 22, 2023 (the “Agreement”).

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