0001193125-23-239185 Sample Contracts

and as Trustee, FIRST SUPPLEMENTAL INDENTURE Dated as of September 21, 2023 to Indenture Dated as of April 23, 2018
First Supplemental Indenture • September 21st, 2023 • Paratek Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

FIRST SUPPLEMENTAL INDENTURE, dated as of September 21, 2023 (this “Supplemental Indenture”), between PARATEK PHARMACEUTICALS, INC., a Delaware corporation, as issuer (the “Company”), and U.S. Bank Trust Company, National Association (f/k/a U.S. Bank National Association), a national banking association, as trustee (the “Trustee”), supplementing the Indenture, dated as of April 23, 2018, between the Company and the Trustee (the “Base Indenture” and the Base Indenture, as amended and supplemented by this Supplemental Indenture, and as it may be further amended, supplemented or otherwise modified from time to time with respect to the Notes, the “Indenture”).

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