0001193125-20-249116 Sample Contracts

NuCana plc 15,555,556 American Depositary Shares Representing an Aggregate of 15,555,556 Ordinary Shares Underwriting Agreement
Letter Agreement • September 18th, 2020 • NuCana PLC • Pharmaceutical preparations • New York

The ADSs will be evidenced by American Depositary Receipts (“ADRs”) issued pursuant to that certain Deposit Agreement, dated as of October 2, 2017 (the “Deposit Agreement”), by and among the Company, Citibank, N.A. as depositary (the “Depositary”), and all holders and beneficial owners of ADSs issued thereunder. The Company shall, following subscription by the Underwriters of the Offered Securities pursuant to this Agreement, deposit, on behalf of the Underwriters, the Shares being delivered in the form of the Offered Securities with Citibank, N.A., London Branch as custodian (the “Custodian”) for the Depositary, which shall deliver the Offered Securities to the Representatives for the account of the several Underwriters for subsequent delivery to the other several Underwriters or the investors, as the case may be.

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