0001193125-19-031026 Sample Contracts

OPKO HEALTH, INC. AND U.S. BANK NATIONAL ASSOCIATION as Trustee FIRST SUPPLEMENTAL INDENTURE Dated as of February 7, 2019 4.50% Convertible Senior Notes due 2025
First Supplemental Indenture • February 7th, 2019 • Opko Health, Inc. • Pharmaceutical preparations • New York

This FIRST SUPPLEMENTAL INDENTURE (this “First Supplemental Indenture”), dated as of February 7, 2019, between OPKO HEALTH, INC., a Delaware corporation, as issuer (the “Company,” as more fully set forth in Section 1.02) and U.S. BANK NATIONAL ASSOCIATION, a national banking association organized and existing under the laws of the United States of America, as trustee (the “Trustee,” as more fully set forth in Section 1.02).

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OPKO HEALTH, INC. and U.S. Bank National Association as Trustee Guaranteed to the extent set forth therein by the Guarantors named herein. INDENTURE dated as of February 7, 2019
Indenture • February 7th, 2019 • Opko Health, Inc. • Pharmaceutical preparations • New York

INDENTURE dated as of February 7, 2019 by and among OPKO HEALTH, INC., a Delaware corporation (the “Company”), the guarantors listed on Schedule 1 hereto (herein called the “Guarantors”), and U.S. BANK NATIONAL ASSOCIATION, as Trustee (the “Trustee”).

SHARE LENDING AGREEMENT Dated as of February 4, 2019 Between OPKO Health, Inc. (“Lender”) and Jefferies Capital Services, LLC (“Borrower”)
Share Lending Agreement • February 7th, 2019 • Opko Health, Inc. • Pharmaceutical preparations • New York

This Agreement sets forth the terms and conditions under which Borrower may, from time to time, borrow from Lender shares of Common Stock.

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