0001193125-18-134207 Sample Contracts

Deed of Charge of Shares Dated 15 September 2017 Between (each referred to as a Party and collectively as the Parties). Recitals
Shin Nippon Biomedical Laboratories, Ltd. • April 26th, 2018 • Pharmaceutical preparations

A Wave Life Sciences Ltd. (Registration No. 201218209G) (WAVE) is a company incorporated under the laws of Singapore and having its registered office at 8 Cross Street, #10-00, PWC Building, Singapore 048424.

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STOCK PLEDGE AGREEMENT
Stock Pledge Agreement • April 26th, 2018 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations • Washington

This STOCK PLEDGE AGREEMENT, dated as of December 28, 2016 (as amended, supplemented or otherwise modified from time to time in accordance with the provisions hereof, this “Agreement”), made by and between SNBL U.S.A., Ltd., a Washington corporation (the “Pledgor”) and The Kagoshima Bank, Ltd., a Japanese banking corporation (the “Secured Party”).

Deed of Charge of Shares Dated 15 September 2017 Between (each referred to as a Party and collectively as the Parties). Recitals
Shin Nippon Biomedical Laboratories, Ltd. • April 26th, 2018 • Pharmaceutical preparations

A Wave Life Sciences Ltd. (Registration No. 201218209G) (WAVE) is a company incorporated under the laws of Singapore and having its registered office at 8 Cross Street, #10-00, PWC Building, Singapore 048424.

SECOND AMENDMENT TO PLEDGE AGREEMENT
Pledge Agreement • April 26th, 2018 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations • Washington

THIS SECOND AMENDMENT TO PLEDGE AGREEMENT is dated as of December 27, 2017 (this “Amendment”) and is made by and between SNBL U.S.A. Ltd., a Washington corporation (“SNBL USA”) and The Kagoshima Bank, Ltd. (“Lender”).

AMENDMENT TO PLEDGE AGREEMENT
Pledge Agreement • April 26th, 2018 • Shin Nippon Biomedical Laboratories, Ltd. • Pharmaceutical preparations • Washington

THIS AMENDMENT TO PLEDGE AGREEMENT is dated as of June 30, 2017 (this “Amendment”) and is made by and between SNBL U.S.A. Ltd., a Washington corporation (“SNBL USA”) and The Kagoshima Bank, Ltd. (“Lender”).

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