0001193125-17-317234 Sample Contracts

LICENSE AND RESEARCH AGREEMENT
License and Research Agreement • October 24th, 2017 • Alpine Immune Sciences, Inc. • Pharmaceutical preparations

If any milestone event is achieved for a Licensed Product before any of the preceding milestone events are achieved for such Licensed Product, then all the milestone payments for such unachieved preceding milestone events will be due and payable with the milestone payment for the milestone event that was achieved. For example, if Regulatory Approval for a Licensed Product is achieved from a [****] without the need to conduct a [****], then the milestone payment of $[****] would be payable along with the milestone payment of $[****] for such Licensed Product.

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LICENSE AND RESEARCH AGREEMENT AMENDMENT NO. 1
License and Research Agreement • October 24th, 2017 • Alpine Immune Sciences, Inc. • Pharmaceutical preparations

This License and Research Agreement Amendment No. 1 (this “Amendment No. 1”) is made effective as of October 20, 2017 (the “Amendment Effective Date”) by and between AIS Operating Co., Inc., f/k/a Alpine Immune Sciences, Inc., a Delaware corporation (“Alpine”), and Kite Pharma, Inc., a Delaware corporation (“Kite”), with reference to the following facts:

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