0001193125-17-136936 Sample Contracts

ARCA BIOPHARMA, INC. AND , AS WARRANT AGENT FORM OF COMMON STOCK WARRANT AGREEMENT DATED AS OF [ ], 20
Common Stock Warrant Agreement • April 25th, 2017 • ARCA Biopharma, Inc. • In vitro & in vivo diagnostic substances • New York

This COMMON STOCK WARRANT AGREEMENT (this “Agreement”), dated as of between ARCA BIOPHARMA, INC., a Delaware corporation (the “Company”), and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “Warrant Agent”).

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ARCA BIOPHARMA, INC. AND , AS WARRANT AGENT FORM OF PREFERRED STOCK WARRANT AGREEMENT DATED AS OF [ ], 20
Preferred Stock Warrant Agreement • April 25th, 2017 • ARCA Biopharma, Inc. • In vitro & in vivo diagnostic substances • New York

This PREFERRED STOCK WARRANT AGREEMENT (this “Agreement”), dated as of between ARCA BIOPHARMA, INC., a Delaware corporation (the “Company”), and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “Warrant Agent”).

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ARCA BIOPHARMA, INC. and , AS WARRANT AGENT FORM OF DEBT SECURITIES WARRANT AGREEMENT DATED AS OF [ ], 20
Debt Securities Warrant Agreement • April 25th, 2017 • ARCA Biopharma, Inc. • In vitro & in vivo diagnostic substances • New York

This DEBT SECURITIES WARRANT AGREEMENT (this “Agreement”), dated as of between ARCA BIOPHARMA, INC., a Delaware corporation (the “Company”), and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “Warrant Agent”).

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