0001193125-16-783858 Sample Contracts

RESTRICTED STOCK SUBSTITUTION AGREEMENT
Restricted Stock Substitution Agreement • December 2nd, 2016 • Acucela Inc. • Pharmaceutical preparations • Tokyo

This Restricted Stock Substitution Agreement (the “Agreement”) is made and entered into as of [Month, Date], [Year], by and between Kubota Pharmaceutical Holdings Co., Ltd., a Japanese corporation (the “Company”), and [Name] (the “Holder”).

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STOCK OPTION SUBSTITUTION AGREEMENT
Stock Option Substitution Agreement • December 2nd, 2016 • Acucela Inc. • Pharmaceutical preparations • Tokyo

This Stock Option Substitution Agreement (the “Agreement”) is made and entered into as of [Month, Date], [Year], by and between Kubota Pharmaceutical Holdings Co., Ltd., a Japanese corporation (the “Company”), and [Name] (the “Holder”).

RESTRICTED STOCK UNIT SUBSTITUTION AGREEMENT
Restricted Stock Unit Substitution Agreement • December 2nd, 2016 • Acucela Inc. • Pharmaceutical preparations • Tokyo

This Restricted Stock Unit Substitution Agreement (the “Agreement”) is made and entered into as of [Month, Date], [Year], by and between Kubota Pharmaceutical Holdings Co., Ltd., a Japanese corporation (the “Company”), and [Name] (the “Holder”).

Liability Limitation Agreement
Liability Limitation Agreement • December 2nd, 2016 • Acucela Inc. • Pharmaceutical preparations

Kubota Pharmaceutical Holdings Co., Ltd. (the “Company”) and [TBD] (“Director”) enter into this agreement (this “Agreement”) as follows in accordance with Article 427, Paragraph 1 of the Companies Act and Article 26, Paragraph 2 of the Articles of Incorporation of the Company.

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