0001193125-16-606607 Sample Contracts

May 25, 2016 Dr. Stelios Papadopoulos SE PAPADOPOULOS LLC
: Letter Agreement • May 27th, 2016 • Proteostasis Therapeutics, Inc. • Pharmaceutical preparations • New York
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Amendment No. 4 to Collaboration and License Agreement
Collaboration and License Agreement • May 27th, 2016 • Proteostasis Therapeutics, Inc. • Pharmaceutical preparations

This Amendment No. 4 to Collaboration and License Agreement (this “Amendment No. 4”) is made and effective as of January 31, 2016, by and between Proteostasis Therapeutics, Inc., a corporation existing under the laws of the State of Delaware, having a place of business at 200 Technology Square, 4th Floor, Cambridge, MA 02139 (“PTI”) and Astellas Pharma Inc., a Japanese corporation having its principal place of business at 5-1 Nihonbashi-Honcho 2-Chome, Chuo-ku, Tokyo 103-8411, Japan (“Astellas”). Each of Astellas and PTI is sometimes referred to individually herein as a “Party” and collectively as the “Parties”.

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