0001193125-16-539975 Sample Contracts

THERMO FISHER SCIENTIFIC INC. as Issuer AND THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee TWELFTH SUPPLEMENTAL INDENTURE Dated as of April 13, 2016 $1,000,000,000 of 3.000% Senior Notes due 2023
Supplemental Indenture • April 13th, 2016 • Thermo Fisher Scientific Inc. • Measuring & controlling devices, nec • New York

THIS TWELFTH SUPPLEMENTAL INDENTURE (the “Twelfth Supplemental Indenture”) is dated as of April 13, 2016 between THERMO FISHER SCIENTIFIC INC., a Delaware corporation (the “Company”), and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., a national banking association (the “Trustee”).

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