0001193125-16-423492 Sample Contracts

SAGE THERAPEUTICS, INC. 3,157,894 Shares of Common Stock Underwriting Agreement (this “Agreement”)
Sage Therapeutics, Inc. • January 7th, 2016 • Pharmaceutical preparations • New York

Sage Therapeutics, Inc., a Delaware corporation (the “Company”), proposes to issue and sell to the several Underwriters listed in Schedule 1 hereto (the “Underwriters”), for whom you are acting as representatives (the “Representatives”), an aggregate of 3,157,894 shares of Common Stock, par value $0.0001 per share (the “Common Stock”), of the Company (the “Underwritten Shares”) and, at the option of the Underwriters, up to an additional 473,684 shares of Common Stock of the Company (the “Option Shares”). The Underwritten Shares and the Option Shares are herein referred to as the “Shares”. The shares of Common Stock of the Company to be outstanding after giving effect to the sale of the Shares are referred to herein as the “Stock”.

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