0001193125-15-004170 Sample Contracts

KARYOPHARM THERAPEUTICS INC. (a Delaware corporation) 3,000,000 Shares of Common Stock UNDERWRITING AGREEMENT
Underwriting Agreement • January 8th, 2015 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations • New York

Notwithstanding the foregoing, and subject to the conditions below, the undersigned may transfer the Lock-Up Securities pursuant to sections (i) through (vi) below without the prior written consent of each of Merrill Lynch and J.P. Morgan, provided that (1) each of Merrill Lynch and J.P. Morgan receive a signed lock-up agreement for the balance of the Lock-Up Period from each donee, trustee, distributee, or transferee, as the case may be, (2) any such transfer shall not involve a disposition for value, (3) in the case of clauses (i) through (iv) below, such transfers are not required to be reported with the Securities and Exchange Commission on Form 4 in accordance with Section 16 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and (4) the undersigned does not otherwise voluntarily effect any public filing or report regarding such transfers:

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