0001193125-14-187472 Sample Contracts

CO-DEVELOPMENT AND COLLABORATION AGREEMENT By and Between AVEO PHARMACEUTICALS, INC. and BIODESIX, INC.

Co-Development and Collaboration Agreement • May 7th, 2014 • Aveo Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

• Contract Type
  Co-Development and Collaboration Agreement
• Filed
  May 7th, 2014
• Company
  Aveo Pharmaceuticals Inc
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

This CO-DEVELOPMENT AND COLLABORATION AGREEMENT (this “Agreement”), dated as of April 9, 2014 (the “Effective Date”), is entered into by and between AVEO PHARMACEUTICALS, INC. (“AVEO”), a Delaware corporation having a principal office at 650 E. Kendall Street, Cambridge, Massachusetts 02142, and Biodesix, Inc. (“Biodesix”), a Delaware corporation having a principal office located at 2970 Wilderness Place, Suite 100, Boulder, Colorado 80301. AVEO and Biodesix are sometimes referred to herein individually as a “Party” and collectively as the “Parties”.

AVEO PHARMACEUTICALS LETTERHEAD]

Aveo Pharmaceuticals Inc • May 7th, 2014 • Pharmaceutical preparations

• Company
  Aveo Pharmaceuticals Inc
• Filed
  May 7th, 2014
• Industry
  Pharmaceutical preparations

To incentivize you to remain with of AVEO Pharmaceuticals, Inc. (the “Company”) and dedicate yourself to its success and to encourage your continued efforts to maximize the Company’s value, the Company would like to (i) offer to you a retention bonus subject to the conditions set forth below in this letter agreement (the “Letter Agreement”) and (ii) amend your Severance and Change in Control Agreement dated as of December 11, 2009 (the “Severance Agreement”). Terms used herein and not otherwise defined shall have such meaning as set forth in the Severance Agreement.

Amendment No. 1 to Option and License Agreement

Option and License Agreement • May 7th, 2014 • Aveo Pharmaceuticals Inc • Pharmaceutical preparations

• Contract Type
  Option and License Agreement
• Filed
  May 7th, 2014
• Company
  Aveo Pharmaceuticals Inc
• Industry
  Pharmaceutical preparations

This is Amendment No. 1 to the Option and License Agreement by and between AVEO Pharmaceuticals, Inc. (“AVEO”) and Biogen Idec International GmbH (“Biogen Idec”) dated as of March 18, 2009 (the “Agreement”). The effective date of this Amendment No. 1 is March 18, 2014 (the “Amendment Effective Date”). Capitalized terms used in this Amendment No. 1 shall have the meanings set forth in the Agreement, except as otherwise provided in this Amendment.