0001193125-14-024391 Sample Contracts

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. Amendment to Collaboration and License Agreement
Collaboration and License Agreement • January 28th, 2014 • Epizyme, Inc. • Pharmaceutical preparations

This Amendment (this “Amendment”) to the Collaboration and License Agreement dated as of January 8, 2011 (the “Agreement”), by and between EPIZYME and GSK is effective as of the 23rd day of July, 2013 (the “Amendment Effective Date”). Capitalized terms used but not defined herein shall have the meanings ascribed to such terms in the Agreement.

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