0001193125-13-382915 Sample Contracts

PROTHENA CORPORATION PLC (an Irish public limited company) — Ordinary Shares UNDERWRITING AGREEMENT
Underwriting Agreement • September 30th, 2013 • Prothena Corp PLC • Pharmaceutical preparations • New York
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AMENDMENT NUMBER ONE AMENDED AND RESTATED INTELLECTUAL PROPERTY LICENSE AND CONTRIBUTION AGREEMENT
Intellectual Property License and Contribution Agreement • September 30th, 2013 • Prothena Corp PLC • Pharmaceutical preparations

This AMENDMENT NUMBER ONE to the AMENDED AND RESTATED INTELLECTUAL PROPERTY LICENSE AND CONTRIBUTION AGREEMENT (the “Amendment”) is made with retroactive effect to December 20, 2012 (the “Amendment Effective Date”), by and among Neotope Biosciences Limited, a private limited company incorporated under the laws of Ireland with offices at 25-28 North Wall Quay, Dublin 1, Ireland (“NBL”), Elan Pharma International Limited, a private limited company incorporated under the laws of Ireland with offices at Treasury Building, Lower Grand Canal Street, Dublin 2, Ireland (“EPIL”), Elan Pharmaceuticals, LLC (f/k/a Elan Pharmaceuticals, Inc), a Delaware limited liability company with offices at 300 Technology Square, Third Floor, Cambridge, Massachusetts, U.S.A. 02139 (“EPI”), Elan Corporation, plc, an Irish public limited company with offices at Treasury Building, Lower Grand Canal Street, Dublin 2, Ireland (“Elan plc”), and Crimagua Limited, a private limited company incorporated under the laws

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