0001193125-12-428299 Sample Contracts

17,500,000 Shares LEXICON PHARMACEUTICALS, INC. COMMON STOCK, PAR VALUE $0.001 PER SHARE UNDERWRITING AGREEMENT

Underwriting Agreement • October 19th, 2012 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • New York

• Contract Type
  Underwriting Agreement
• Filed
  October 19th, 2012
• Company
  Lexicon Pharmaceuticals, Inc./De
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

The undersigned understands that J.P. Morgan Securities LLC (“J.P. Morgan”) and Jefferies & Company, Inc. (“Jefferies”) propose to enter into an Underwriting Agreement (the “Underwriting Agreement”) with Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”), providing for the public offering (the “Public Offering”) by the several Underwriters, including J.P. Morgan and Jefferies (the “Underwriters”), of shares (the “Shares”) of the common stock, par value $0.001 per share, of the Company (the “Common Stock”).