0001193125-12-231684 Sample Contracts

SEVENTH AMENDMENT AGREEMENT
Seventh Amendment Agreement • May 14th, 2012 • RXi Pharmaceuticals Corp • Pharmaceutical preparations

This SEVENTH AMENDMENT AGREEMENT (this “Seventh Amendment”) is made and entered into as of April 25, 2012, by and among Tang Capital Partners, LP, RTW Investments, LLC, Galena Biopharma, Inc. (formerly RXi Pharmaceuticals Corporation, “Galena”) and RXi Pharmaceuticals Corporation (formerly RNCS, Inc., “RXi”).

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THIRD OMNIBUS AMENDMENT
Third Amendment • May 14th, 2012 • RXi Pharmaceuticals Corp • Pharmaceutical preparations

This THIRD OMNIBUS AMENDMENT (this “Third Amendment”) is made and entered into as of March 30, 2012, by and among Tang Capital Partners, LP, RTW Investments, LLC, Galena Biopharma, Inc. (formerly RXi Pharmaceuticals Corporation) and RXi Pharmaceuticals Corporation (formerly RNCS, Inc.).

FOURTH OMNIBUS AMENDMENT
Fourth Omnibus • May 14th, 2012 • RXi Pharmaceuticals Corp • Pharmaceutical preparations

This FOURTH OMNIBUS AMENDMENT (this “Fourth Amendment”) is made and entered into as of April 3, 2012, by and among Tang Capital Partners, LP, RTW Investments, LLC, Galena Biopharma, Inc. (formerly RXi Pharmaceuticals Corporation) and RXi Pharmaceuticals Corporation (formerly RNCS, Inc.).

SECOND OMNIBUS AMENDMENT
Second Amendment • May 14th, 2012 • RXi Pharmaceuticals Corp • Pharmaceutical preparations

This SECOND OMNIBUS AMENDMENT (this “Second Amendment”) is made and entered into as of March 5, 2012, by and among Tang Capital Partners, LP, RTW Investments, LLC, Galena Biopharma, Inc. (formerly RXi Pharmaceuticals Corporation) and RXi Pharmaceuticals Corporation (formerly RNCS, Inc.).

OMNIBUS AMENDMENT
Omnibus Amendment • May 14th, 2012 • RXi Pharmaceuticals Corp • Pharmaceutical preparations

This OMNIBUS AMENDMENT (this “Amendment”) is made and entered into as of February 6, 2012, by and among Tang Capital Partners, LP, RTW Investments, LLC, Galena Biopharma, Inc. (formerly RXi Pharmaceuticals Corporation) and RXi Pharmaceuticals Corporation (formerly RNCS, Inc.).

FIFTH OMNIBUS AMENDMENT
Fifth Amendment • May 14th, 2012 • RXi Pharmaceuticals Corp • Pharmaceutical preparations

This FIFTH OMNIBUS AMENDMENT (this “Fifth Amendment”) is made and entered into as of April 11, 2012, by and among Tang Capital Partners, LP, RTW Investments, LLC, Galena Biopharma, Inc. (formerly RXi Pharmaceuticals Corporation) and RXi Pharmaceuticals Corporation (formerly RNCS, Inc.).

SIXTH OMNIBUS AMENDMENT
Sixth Amendment • May 14th, 2012 • RXi Pharmaceuticals Corp • Pharmaceutical preparations

This SIXTH OMNIBUS AMENDMENT (this “Sixth Amendment”) is made and entered into as of April 18, 2012, by and among Tang Capital Partners, LP, RTW Investments, LLC, Galena Biopharma, Inc. (formerly RXi Pharmaceuticals Corporation) and RXi Pharmaceuticals Corporation (formerly RNCS, Inc.).

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