0001193125-12-153625 Sample Contracts

EIGHTH SUPPLEMENTAL INDENTURE
Eighth Supplemental Indenture • April 6th, 2012 • Medco Health Solutions Inc • Retail-drug stores and proprietary stores • New York

The Eighth Supplemental Indenture (this “Eighth Supplemental Indenture”), dated as of April 2, 2012, among Express Scripts, Inc., a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), the Guarantors listed as signatories hereto (each, an “Existing Guarantor” and collectively, the “Existing Guarantors”), Medco Health Solutions, Inc., a Delaware corporation, and its subsidiaries listed as signatories hereto (each, an “Additional Guarantor,” and, collectively, the “Additional Guarantors”) and Union Bank, N.A., a national association, as trustee under the indenture referred to below (the “Trustee”).

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FIRST SUPPLEMENTAL INDENTURE
Supplemental Indenture • April 6th, 2012 • Medco Health Solutions Inc • Retail-drug stores and proprietary stores • New York

FIRST SUPPLEMENTAL INDENTURE (this “First Supplemental Indenture”), dated as of April 2, 2012, among Medco Health Solutions, Inc., a Delaware corporation (the “Company”), the entities listed on Schedule I hereto, each a subsidiary of the Company (each, a “Subsidiary Guarantor” and, collectively, the “Subsidiary Guarantors”), and U.S. Bank Trust National Association, as trustee under the indenture referred to below (the “Trustee”).

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