0001193125-10-180720 Sample Contracts

FIRST AMENDMENT TO DEVELOPMENT, LICENSE AND SUPPLY AGREEMENT
Development, License and Supply Agreement • August 6th, 2010 • Inspire Pharmaceuticals Inc • Pharmaceutical preparations

This First Amendment to Development, License and Supply Agreement dated as of June 3, 2010 (this “Amendment”), is entered into by and between Inspire Pharmaceuticals, Inc., a corporation organized and existing under the laws of the State of Delaware, having offices located at 4222 Emperor Boulevard, Suite 200, Durham, North Carolina 27703, USA (“Inspire”), and Santen Pharmaceutical Co., Ltd., a corporation organized under the laws of Japan, having offices located at 3-9-19 Shimoshinjo, Higashiyodogawa-ku, Osaka, 533-8651, Japan (“Santen”).

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