0001193125-09-170798 Sample Contracts

22,222,223 Shares INSPIRE PHARMACEUTICALS, INC. Common Stock ($0.001 Par Value) UNDERWRITING AGREEMENT
Underwriting Agreement • August 10th, 2009 • Inspire Pharmaceuticals Inc • Pharmaceutical preparations • New York
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WARBURG PINCUS PRIVATE EQUITY IX, L.P. New York, NY 10017
Inspire Pharmaceuticals Inc • August 10th, 2009 • Pharmaceutical preparations

In connection with the acquisition of shares of Common Stock, par value $0.001 per share (the “Common Stock”), of Inspire Pharmaceuticals, Inc., a Delaware corporation (the “Company”), by Warburg Pincus Private Equity IX, L.P., a Delaware limited partnership (the “Purchaser”), in relation to the Company’s public offering of Common Stock pursuant to the Prospectus Supplement dated August 4, 2009 (including any related free writing prospectus and any amendment thereof or supplement thereto dated on or prior to September 30, 2009, and excluding any thereafter) and the related Registration Statement (File No. 333-141169) (the “Public Offering”), the Company and the Purchaser agree as follows:

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