0001193125-09-103372 Sample Contracts

AMENDED AND RESTATED MANUFACTURING AGREEMENT
Manufacturing Agreement • May 7th, 2009 • Targeted Genetics Corp /Wa/ • Biological products, (no disgnostic substances) • California

THIS AMENDED AND RESTATED MANUFACTURING AGREEMENT (the “Agreement”) is made effective as of February 25, 2009 (the “Amendment Date”) by and between CELLADON CORPORATION, a California corporation, with its principal place of business at 2223 Avenida de la Playa, Suite 300, c/o Enterprise Partners Venture Capital, La Jolla, CA 92037 (“Celladon”), and TARGETED GENETICS CORPORATION, a Washington corporation with its principal offices at 1100 Olive Way, Suite 100, Seattle, Washington 98101 (“TGC”).

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LICENSE AGREEMENT Supersedes and replaces Collaboration Agreement
License Agreement • May 7th, 2009 • Targeted Genetics Corp /Wa/ • Biological products, (no disgnostic substances) • California

THIS LICENSE AGREEMENT (the “Agreement”), effective as of February 25, 2009 (the “Effective Date”), is entered into by and between CELLADON CORPORATION, a California corporation (“Celladon”), with its principal place of business at 2223 Avenida de la Playa, Suite 300, c/o Enterprise Partners Venture Capital, La Jolla, CA 92037, and TARGETED GENETICS CORPORATION, a Washington corporation (“TGC”), with its principal place of business at 1100 Olive Way, Suite 100, Seattle, WA 98101.

CONFIDENTIAL UNIVERSITY OF PENNSYLVANIA AMENDED AND RESTATED LICENSE AGREEMENT
License Agreement • May 7th, 2009 • Targeted Genetics Corp /Wa/ • Biological products, (no disgnostic substances) • Pennsylvania

This Amended and Restated License Agreement (“Agreement”), effective January 29, 2009 ( the “Restatement Date”) is made by and between The Trustees of the University of Pennsylvania, a Pennsylvania nonprofit corporation, with offices located at 3160 Chestnut Street, Suite 200, Philadelphia, Pennsylvania 19104-6283 (“Penn”) and Targeted Genetics Corporation, a corporation organized and existing under the laws of Washington (“Targeted”), having a place of business at 1100 Olive Way, Suite 100, Seattle, Washington 98101 and is an amendment to and restatement of the original License Agreement between Targeted and Penn (the “Original Agreement”) which became effective on June 1, 2002 (the “Effective Date”).

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